Principle and Practice of Fragment Based Lead Discovery

[Principle and practice of fragment based lead discovery].

Fragment - based Lead Discovery

Fragment-Based Lead Discovery by NMR

fragment-based lead discovery because it combines high sensitivity and robustness to loose fragment binders with unique structural resolution and throughput. Favourable applications include screening against shallow binding pockets (such as protein-protein interactions) and side-pockets outside the highly conserved active centre of the major target classes (such as protein kinases and proteases...

The Role of Fragment-based Discovery in Lead Finding

Process of Fragment-Based Lead Discovery-A Perspective from NMR.

Fragment-based lead discovery (FBLD) has proven fruitful during the past two decades for a variety of targets, even challenging protein-protein interaction (PPI) systems. Nuclear magnetic resonance (NMR) spectroscopy plays a vital role, from initial fragment-based screening to lead generation, because of its power to probe the intrinsically weak interactions between targets and low-molecular-we...